Neurochemical sex differences in adult ADHD patients: an MRS study

Endres, Dominique; Tebartz van Elst, Ludger; Maier, Simon J.; Feige, Bernd; Goll, Peter; Meyer, Simon A.; Matthies, Swantje; Domschke, Katharina; Lange, Thomas; Sobanski, Esther; Philipsen, Alexandra; Nickel, Kathrin; Perlov, Evgeniy

doi:10.1186/s13293-019-0264-4

Biology of Sex Differences

Table 4 Spectroscopic findings in the pACC and the cerebellum

From: Neurochemical sex differences in adult ADHD patients: an MRS study

	mADHD (n = 48)	fADHD (n = 48)	Robust linear regression	mADHD (n = 42)	fADHD (n = 42)	Robust linear regression
	pACC			Cerebellum
Cre	8.8544 ± 1.16232	8.9506 ± 1.31720	Sex: F = 0.017, p = 0.894, p_corr = 0.894	9.3584 ± 1.01449	9.1434 ± 1.30337	Sex: F = 2.39, p = 0.115, p_corr = 0.191
			Age: F = 8.305, p = 0.003, p_corr = 0.008			Age: F = 0.237, p = 0.620, p_corr = 0.775
			BDI: F = 0.851, p = 0.347, p_corr = 0.382			BDI: F = 0.914, p = 0.330, p_corr = 0.575
			Sex:age: F = 6.736, p = 0.008, p_corr = 0.033			Sex: age: F = 1.382, p = 0.231, p_corr = 0.438
t-Cho	2.3481 ± .33682	2.1581 ± .42736	Sex: F = 4.869, p = 0.025*, p_corr = 0.123	2.3634 ± 0.32890	2.2010 ± 0.35128	Sex: F = 6.054, p = 0.012, p_corr = 0.049**
			Age: F = 11.022, p < 0.001, p_corr = 0.004**			Age: F = 2.818, p = 0.087, p_corr = 0.159
			BDI: F = 4.278, p = 0.035*, p_corr = 0.175			BDI: F = 1.079, p = 0.290, p_corr = 0.575
			Sex:age: F = 4.921, p = 0.024, p_corr = 0.040			Sex:age: F = 1.021, p = 0.303, p_corr = 0.438
Glx	16.1562 ± 2.39563	16.1508 ± 2.49773	Sex: F = 0.486, p = 0.477, p_corr = 0.894	11.1479 ± 1.51264	10.4854 ± 2.11368	Sex: F = 5.242, p = 0.020, p_corr = 0.049
			Age: F = 0.019, p = 0.888, p_corr = 0.888			Age: F = 3.005, p = 0.077, p_corr = 0.159
			BDI: F = 0.736, p = 0.382, p_corr = 0.382			BDI: F = 0.303, p = 0.575, p_corr = 0.575
			Sex:age: F = 5.933, p = 0.013, p_corr = 0.033			Sex:age: F = 0.556, p = 0.448, p_corr = 0.448
NAA	11.2331 ± 1.82291	11.6514 ± 1.25699	Sex: F = 0.361, p = 0.541, p_corr = 0.894	8.9707 ± 0.98168	9.0642 ± 0.93218	Sex: F = 0.927, p = 0.327, p_corr = 0.408
			Age: F = 3.657, p = 0.051, p_corr = 0.086			Age: F = 0.016, p = 0.897, p_corr = 0.897
			BDI: F = 0.835, p = 0.352, p_corr = 0.382			BDI: F = 0.664, p = 0.406, p_corr = 0.575
			Sex:age: F = 3.629, p = 0.052, p_corr = 0.065			Sex:age: F = 0.840, p = 0.350, p_corr = 0.438
mI	6.1587 ± 0.96007	6.1954 ± 0.94481	Sex: F = 0.031, p = 0.859, p_corr = 0.894	4.8784 ± 0.84957	4.7396 ± 0.82911	Sex: F = 0.413, p = 0.513, p_corr = 0.513
			Age: F = 1.508, p = 0.211, p_corr = 0.264			Age: F = 2.683, p = 0.095, p_corr = 0.159
			BDI: F = 2.931, p = 0.0811, p_corr = 0.203			BDI: F = 0.439, p = 0.450, p_corr = 0.575
			Sex:age: F = 0.255, p = 0.607, p_corr = 0.607			Sex:age: F = 1.334, p = 0.239, p_corr = 0.438

Abbreviations: mADHD male ADHD patients, fADHD female ADHD patients, pACC pregenual anterior cingulate cortex, BDI Beck depression inventory, Cre creatine, t-Cho phosphorylcholine + glycerylphosphorylcholine, Glx glutamate + glutamine, NAA N-acetylaspartate, mI myo-inositol, pcorr corrected p values using the Benjamini-Hochberg approach
*Significantly different (printed in bold)

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ISSN: 2042-6410

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