Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Table 2 MSC viability, function, and immunocytochemistry of fat tissue in women with normotensive vs. preeclamptic pregnancies

Variable	Normotensive/preeclamptic samples	Normotensive	Preeclampsia	p
Live cells, %	12/10	92.47 (91.53–93.41)	88.50 (85.12–91.86)	0.012
Dead cells, %	12/10	4.21 (3.57–4.86)	7.16 (4.41–9.91)	0.019
Proliferation (OD)^x	10/7	0.80 (0.62–0.99)	0.44 (0.32–0.57)	0.005
Migration (OD)^x	10/7	1.30 (0.99–1.61)	1.88 (1.42–2.33)	0.023
DHE^†	12/9	0.287 (0.241–0.334)	0.352 (0.284–0.419)	0.084
TNF-alpha^†	12/9	0.090 (0.058–0.122)	0.284 (0.210–0.358)	< 0.001
MCP-1^†	12/9	0.058 (0.041–0.075)	0.085 (0.069–0.101)	0.024

Results are expressed as mean (95% CI)
DHE dihydroethidium, TNF-alpha tumor necrosis factor-alpha, MCP-1 monocyte chemoattractant protein-1, OD optical density units
^xProliferation and migration measured at 490 and 560 nm wavelengths, respectively
^†Expressed as the percent of the field-of-view staining (average of 4–6 fields)

ISSN: 2042-6410