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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Fig. 5

Apoptotic effects of the senolytic agent, dasatinib, on MSC. Dose-response experiments showed that PE-MSCs are sensitive to a lower concentration (1 μM) of dasatinib, while the apoptotic effect of the drug is lower at higher concentrations of the drug (a). Treatment with 1 μM dasatinib revealed significant apoptotic effects in PE-MSC (p = 0.0117) compared to the non-treated cells, but not in NP-MSC (p = 0.0934). Representative image shows apoptotic cells stained red for PE-MSC and NP-MSC in all three conditions (medium, vehicle, treatment) (n = 3) (b)

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