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Fig. 1 | Biology of Sex Differences

Fig. 1

From: Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells

Fig. 1

Growth characteristics of colonoids from male and female mice and impact of PAR2 activation. a Colonoids were counted and measured as described in the “Methods” section at day 6 after male and female colon crypts seeding in Matrigel. Representative colonoids are shown. b Colonoids from male and female mice were stimulated daily with PAR2 agonist peptide (SLIGRL-NH2, 100 μM) or control peptide (LRGILS-NH2, 100 μM) from day 2 to day 6 of culture. At day 6 of culture, colonoids were counted and their size measured. Results are mean ± SEM from n = 5 independent experiments

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