TY - JOUR AU - Noguerol, Julie AU - Roustan, Pierre-Jean AU - N’Taye, Mikael AU - Delcombel, Léo AU - Rolland, Corinne AU - Guiraud, Laura AU - Sagnat, David AU - Edir, Anissa AU - Bonnart, Chrystelle AU - Denadai-Souza, Alexandre AU - Deraison, Céline AU - Vergnolle, Nathalie AU - Racaud-Sultan, Claire PY - 2019 DA - 2019/09/06 TI - Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells JO - Biology of Sex Differences SP - 47 VL - 10 IS - 1 AB - Sexual dimorphism in biological responses is a critical knowledge for therapeutic proposals. However, gender differences in intestinal stem cell physiology have been poorly studied. Given the important role of the protease-activated receptor PAR2 in the control of colon epithelial primitive cells and cell cycle genes, we have performed a sex-based comparison of its expression and of the effects of PAR2 activation or knockout on cell proliferation and survival functions. SN - 2042-6410 UR - https://doi.org/10.1186/s13293-019-0262-6 DO - 10.1186/s13293-019-0262-6 ID - Noguerol2019 ER -