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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice

Fig. 5

Administration of 17β-estradiol to obese transwomen initiating gender-affirming hormone therapy increases plasma concentrations of 17β-estradiol, which correlates positively to plasma Ang-(1-7)/AngII balance and negatively to systolic blood pressures (SBP). a Plasma 17β-estradiol concentrations before (baseline) and after administration of 17β-estradiol to obese transwomen for 12 weeks. b Scatterplot showing the correlation between the ratio of Ang-(1-7) to AngII concentrations in plasma to plasma 17β-estradiol concentrations after 12 weeks of 17β-estradiol administration. c Scatterplot showing correlation between change in SBP and the ratio of Ang-(1-7) to AngII in plasma following 12 weeks 17β-estradiol administration. N = 4 subjects. *p < 0.05 compared to baseline

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