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Fig. 3 | Biology of Sex Differences

Fig. 3

From: Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice

Fig. 3

ACE2 deficiency in adipocytes increases blood pressures of obese female, but not obese male mice. Systolic blood pressures (SBP, 24-h average) (a) of female Ace2fl/fl and male Ace2fl/y and Ace2Adipo mice fed a LF or HF diet for 4 months. Diastolic blood pressures (DBP) (b) of female and male mice of each genotype fed the LF or HF diet for 4 months. Data are mean + SEM from 4–5 mice/genotype/diet. *p < 0.01 compared to LF within sex using two-way ANOVA followed by Holm-Sidak pairwise analysis; #p < 0.05 compared to Ace2fl/fl within sex group using two-way ANOVA followed by Holm-Sidak pairwise analysis; @p < 0.01 compared to female within diet group using two-way ANOVA followed by Holm-Sidak pairwise analysis

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