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Table 3 Male-biased expression of transcription and epigenetic factors

From: The developmental origins of sex-biased expression in cardiac development

Transcription factors and epigenetic and remodelling enzymes

ES

CP

8.5

9.5

10.5

p1

Adult

Chr

Name

Egr4

XY

      

6

Early growth response 4

Cdx1

XY

      

18

Caudal type homeobox 1

E2f7

XY

      

10

E2F transcription factor 7

Eomes

XY

      

9

Eomesodermin

Evx1

XY

      

6

Even-skipped homeobox 1

Foxi3

XY

      

6

Forkhead box I3

Foxp4

XY

      

17

Forkhead box P4

Insm1

XY

      

2

Insulinoma-associated 1

Lin28a

XY

      

4

Lin-28 homolog A (C. elegans)

Mesp1

XY

      

7

Mesoderm posterior 1

Mixl1

XY

      

1

Mix1 homeobox-like 1 (Xenopus laevis)

Nr6a1

XY

      

2

Nuclear receptor subfamily 5, group A, member 1

Pou2f3

XY

      

9

POU domain, class 2, transcription factor 3

Sox11

XY

      

12

SRY (sex determining region Y)-box 11

Sp5

XY

      

9

Per-hexamer repeat gene 4

Sp8

XY

      

12

Trans-acting transcription factor 8

T

XY

      

17

Brachyury, T-box transcription factor T

Tcf7

XY

      

11

Transcription factor 7, T cell specific

Wiz

XY

      

17

Widely-interspaced zinc finger motifs

Ybx2

XY

      

11

Y box protein 2

Zglp1

XY

      

9

Zinc finger, GATA-like protein 1

Dnmt3b

XY

      

2

DNA methyltransferase 3B

Dnmt3l

XY

      

10

DNA (cytosine-5-)-methyltransferase 3-like

Phc1

XY

      

6

Polyhomeotic 1

Plac8

XY

      

5

Placenta-specific 8

Tdrd5

XY

      

1

Tudor domain containing 5

Bahcc1

XY

      

11

BAH domain and coiled-coil containing 1

Kdm6c

XY

XY

XY

XY

XY

 

XY

Y

Ubiq.transcribed tetratricopeptide repeat gene, Y chr

Bcl6b

XY

XY

    

nb

11

B cell CLL/lymphoma 6, member B

Irf8

XY

XY

    

nb

8

Interferon regulatory factor 8

Arid1a

XY

XY

     

4

AT rich interactive domain 1A (SWI-like)

Lef1

XY

 

XY

  

XY

XY

3

Lymphoid enhancer binding factor 1

Tbx20

XY

XY

  

XY

XY

 

9

T-box 20

Smarcd1

XY

    

XY

 

15

SWI/SNF related, matrix assoc., actin-dep. reg. of chromatin d1

Zbtb7a

XY

    

XY

 

10

Zinc finger and BTB domain containing 7a

Hif3a

XY

XY

   

XY

 

7

hypoxia inducible factor 3, alpha subunit

Nfkb2

XY

    

XY

XY

19

nuclear factor of κ light polypeptide enhancer B cells 2, p49/p100

Pbx2

XY

    

XY

nb

17

Pre B cell leukemia homeobox 2

Prdm6

XY

     

XY

18

PR domain containing 6

Id2

XY

     

XY

12

Inhibitor of DNA binding 2

Dot1l

XY

    

XY

XX

10

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

Zfp296

XY

    

XX

 

7

Zinc finger protein 296

Gata4

XY

     

nb

14

GATA binding protein 4

Mycn

XY

     

nb

12

v-myc avian myelocytomatosis related og, neuroblastoma derived

Hdac5

XY

     

nb

11

Histone deacetylase 5

Nfxl1

XY

     

nb

5

Nuclear transcription factor, X-box binding-like 1

Pax6

nb

XY

     

2

Paired box 6

Brd4

nb

XY

    

nb

17

Bromodomain containing 4

Carhsp1

nb

 

XY

  

XY

XY

16

Calcium regulated heat stable protein 1

Csde1

nb

 

XY

XY

 

nb

nb

3

Cold shock domain containing E1, RNA binding

Mef2d

nb

    

XY

 

3

Myocyte enhancer factor 2D

Atf5

nb

     

XY

7

activating transcription factor 5

Bach2

nb

     

XY

4

BTB and CNC homology, basic leucine zipper transcription factor 2

Cdc5l

nb

     

XY

17

Cell division cycle 5-like (S. pombe)

Crebzf

nb

     

XY

7

CREB/ATF bZIP transcription factor

Gm13139

nb

     

XY

4

Zinc finger protein 991

Hmgb1

nb

     

XY

2

Predicted gene, 21596

Hmgb2

nb

     

XY

8

High mobility group box 2

Klf10

nb

     

XY

15

Kruppel-like factor 10

Nfic

nb

     

XY

10

Nuclear factor I/C

Nfkb1

nb

     

XY

3

Nuclear factor of κ light polypeptide enhancer in B cells 1, p105

Pias2

nb

     

XY

18

Protein inhibitor of activated STAT 2

  1. ES embryonic stem cells; CP cardiac precursors; 8.5, 9.5, 10.5 days post coitum (dpc) embryonic hearts (single cell); p1 neonatal hearts; Chr chromosome; empty cells expression not detected; nb expressed but not biased