Fig. 1

Weighted gene co-expression network analysis (WGCNA) for male and female ES cells. Expression modules were identified by weighted gene co-expression network analysis. Gene dendrograms display the co-expression modules identified by WGCNA from expression data from 6 male and 6 female ES cell lines and labeled by different colors. Dendrograms were generated by unsupervised hierarchical clustering of genes using topological overlap to identify co-expressed genes in modules. The significantly preserved modules are denoted by the striped colors in the bars below the dendrogram along the x-axis, referred to as the merged dynamic. The bars below the merged dynamic express correlation with sex, cross and RNA-seq batch. The y-axis shows the heights where the clusters merged