Fig. 5

Angiotensin-(1-7) improves glucose-stimulated insulin levels in male and female mice. a, b Raw data curves showing changes in plasma insulin from baseline levels over time in response to glucose (dextrose) administration in control diet- and high-fat diet (HFD)-fed male and female mice chronically treated with Ang-(1-7) versus saline (n = 8–12/group). c, d Data were summarized as an area under the curve (AUC), with a more positive number representing higher levels of insulin in the blood after glucose administration. There were no differences in increases in insulin levels in response to dextrose between diet and sex groups. Ang-(1-7) increased glucose-stimulated insulin levels, with no interactions with diet or sex. Data are mean ± SEM and were analyzed by multiple regression for main effects of sex (P_Sex), diet (P_Diet), and drug (P_Drug) and their pairwise interactions (P_Drug:Sex, P_Diet:Sex, and P_Drug:Diet)