Fig. 4

Angiotensin-(1-7) improves glucose tolerance only in obese female mice. a, b Raw data curves showing changes in blood glucose from baseline levels over time in response to dextrose administration in control diet and high-fat diet (HFD)-induced obese male and female mice chronically treated with Ang-(1-7) or saline (n = 8–12/group). c, d Data were summarized as an area under the curve (AUC), with a more positive number representing higher levels of glucose remaining in the blood over time after dextrose or glucose intolerance. HFD produced similar glucose intolerance in males and females (more positive AUC compared to control diet). Ang-(1-7) selectively improved glucose tolerance in obese female mice. Data are mean ± SEM and were analyzed by multiple regression for main effects of sex (P_Sex), diet (P_Diet), and drug (P_Drug) and their pairwise interactions (P_Drug:Sex, P_Diet:Sex, and P_Drug:Diet)