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Fig. 2 | Biology of Sex Differences

Fig. 2

From: Sex differences in metabolic effects of angiotensin-(1-7) treatment in obese mice

Fig. 2

Angiotensin-(1-7) does not alter fasting glucose or insulin levels. Circulating glucose and insulin levels were measured after a 4-h fasting period in control diet and high-fat diet (HFD)-induced obese male and female mice chronically treated with angiotensin (Ang)-(1-7) or saline (n = 8–12/group). a, b HFD tended to produce mild hyperglycemia, which was not different between sexes and not significantly affected by chronic Ang-(1-7) infusion. c, d HFD produced hyperinsulinemia in both sexes, but to a greater extent in male mice. There was no effect of Ang-(1-7) infusion on insulin levels. Data are mean ± SEM and were analyzed by multiple regression for main effects of sex (PSex), diet (PDiet), and drug (PDrug) and their pairwise interactions (PDrug:Sex, PDiet:Sex, and PDrug:Diet)

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