Fig. 1

Angiotensin-(1-7) improves body composition in obese male and female mice. Body composition was measured at end of treatment in control diet and high-fat diet (HFD)-induced obese male and female mice chronically treated with angiotensin (Ang)-(1-7) or saline (n = 8–12/group). a, b HFD increased body mass in both sexes; however, males had higher body mass on control diet and HFD compared with females. Ang-(1-7) reduced body mass in obese mice of both sexes. c, d HFD increased adiposity to a similar extent in male and female mice. Ang-(1-7) reduced adiposity in both obese male and female mice. e, f HFD reduced lean mass to a similar extent in male and female mice. Ang-(1-7) improved lean mass in obese mice of both sexes. g, h Female mice had higher fluid mass compared with males, particularly under control diet conditions. HFD increased fluid mass in male and female mice, and chronic Ang-(1-7) treatment reduced fluid mass in obese mice of both sexes. Data are mean ± SE and were analyzed by multiple regression for main effects of sex (P_Sex), diet (P_Diet), and drug (P_Drug) and their pairwise interactions (P_Drug:Sex, P_Diet:Sex, and P_Drug:Diet)