Sex differences in brain activation patterns with mental stress in patients with coronary artery disease

Kasher, Nicole; Wittbrodt, Matthew T.; Alam, Zuhayr S.; Lima, Bruno B.; Nye, Jonathon A.; Campanella, Carolina; Ladd, Stacy; Hammadah, Muhammad; Shah, Amit J.; Raggi, Paolo; Quyyumi, Arshed A.; Vaccarino, Viola; Bremner, J. Douglas

doi:10.1186/s13293-019-0248-4

Biology of Sex Differences

Table 5 Brain regions with significantly (one tailed Z > 2.75, p < 0.005) greater mental stress-induced activation or deactivation, as measured with [¹⁵O]H₂O positron emission tomography, in women (n = 9) relative to men (n = 35) with CAD and mental stress-induced myocardial ischemia

From: Sex differences in brain activation patterns with mental stress in patients with coronary artery disease

Voxel number	Brain region	Brodmann’s area	Talairach			Z score
Voxel number	Brain region	Brodmann’s area	X	Y	Z	Z score
Stress activation in women > men
24	L cerebellum		− 26	− 40	− 18	5.70
54	R parietal lobe, postcentral gyrus	40	51	− 32	50	5.44
112	L cerebellum		− 18	− 69	− 18	5.05
	L cerebellum		− 14	− 76	− 13	3.54
67	R parietal lobe, inferior lobule	40	48	− 58	46	4.97
35	R cerebellum		46	− 63	− 19	4.53
33	R cerebellum		10	− 72	− 10	4.38
112	R posterior cingulate	31	8	− 43	41	4.35
	R parietal lobe, precuneus	7	4	− 51	38	4.18
12	L occipital lobe, fusiform gyrus	19	− 42	− 65	− 9	4.13
110	L cerebellum		− 46	− 38	− 32	4.07
	L cerebellum		− 44	− 48	− 25	3.33
	L cerebellum		− 53	− 44	− 35	3.14
47	L cerebellum		− 42	− 61	− 17	4.02
36	R frontal lobe, inferior gyrus	44	59	12	13	3.91
14	R temporal lobe, middle gyrus	39	40	− 65	15	3.81
15	R parietal lobe, postcentral gyrus	3	59	− 13	44	3.77
20	R frontal lobe, superior gyrus	9	42	37	32	3.66
15	L frontal lobe, superior gyrus	10	− 22	63	12	3.54
19	R cerebellum		24	− 50	− 24	3.54
41	R parietal lobe, inferior lobule	40	38	− 52	53	3.48
15	L frontal lobe, middle gyrus	11	− 24	32	− 12	3.37
13	R frontal lobe, superior gyrus	8	14	48	36	3.33
12	L parietal lobe, inferior lobule	40	− 61	− 33	33	3.26
14	R cerebellum		22	− 75	− 15	3.18
14	R frontal lobe, superior gyrus	10	42	48	23	2.89
Stress deactivation in women > men
129	R frontal lobe, inferior gyrus	47	24	22	− 20	5.66
	R frontal lobe, orbital gyrus	47	22	30	− 23	4.01
51	R frontal lobe, superior gyrus	6	14	22	51	5.47
37	L frontal lobe, medial gyrus	6	− 14	29	36	4.95
88	R frontal lobe, inferior gyrus	47	44	27	− 6	4.94
	R frontal lobe, inferior gyrus	47	50	34	− 15	3.80
33	L parietal lobe, supramarginal gyrus	40	− 63	− 43	27	4.91
52	L frontal lobe, superior gyrus	6	− 4	12	55	4.56
24	L anterior cingulate	24	− 4	23	24	4.54
17	L parietal lobe, superior lobule	7	− 26	− 64	50	4.41
42	R temporal lobe, middle gyrus	21	69	− 45	− 8	4.25
	R temporal lobe, inferior gyrus	20	67	− 47	− 15	2.82
69	L parietal lobe postcentral gyrus	40	− 26	− 38	49	4.20
	L parietal lobe, postcentral gyrus	5	− 30	− 44	58	3.75
30	L frontal lobe, precentral gyrus	44	− 63	12	9	4.17
	L frontal lobe, inferior gyrus	45	− 59	18	6	3.94
53	R temporal lobe, inferior gyrus	21	61	− 9	− 16	4.16
54	R frontal lobe, subcallosal gyrus	34	16	7	− 14	4.15
24	R frontal lobe, medial gyrus	9	22	38	23	4.04
14	L frontal lobe, superior gyrus	8	0	28	49	3.98
53	L frontal lobe, inferior gyrus		− 53	18	1	3.97
	L frontal lobe, inferior gyrus	47	− 46	14	− 1	3.15
46	R frontal lobe, medial gyrus	10	10	53	16	3.97
26	R frontal lobe, middle gyrus	8	28	16	43	3.93
	R frontal lobe, middle gyrus	8	24	22	46	3.24
15	L frontal lobe, superior gyrus	8	− 22	16	48	3.83
86	R frontal lobe, middle gyrus	10	44	50	− 7	3.80
	R frontal lobe, middle gyrus	11	40	46	− 17	3.63
32	L thalamus		− 16	− 27	3	3.78
32	R parietal lobe, supramarginal gyrus	40	59	− 47	29	3.73
	R parietal lobe, inferior lobule	40	51	− 52	38	3.60
11	R limbic lobe, cingulate gyrus	32	2	27	34	3.72
30	R temporal lobe, superior gyrus	22	51	12	− 2	3.70
	R temporal lobe, superior gyrus	38	46	13	− 9	3.62
35	L frontal lobe, paracentral lobule	5	− 12	− 42	59	3.69
31	L frontal lobe, medial gyrus	10	− 6	55	7	3.64
20	R lentiform nucleus		16	− 7	5	3.61
34	L frontal lobe, paracentral lobule	5	− 6	− 38	52	3.61
	L parietal lobe, precuneus	7	− 12	− 42	47	3.53
51	R posterior cingulate	29	4	− 36	13	3.53
12	L frontal lobe, middle gyrus	6	− 38	12	46	3.41
18	R anterior cingulate	25	4	9	− 7	3.39
14	L frontal lobe, inferior gyrus	10	− 42	45	3	3.39
20	L frontal lobe, precentral gyrus	4	− 44	− 18	36	3.39
12	L frontal lobe, precentral gyrus	4	− 36	− 24	55	3.38
22	L parietal lobe, postcentral gyrus	3	− 30	− 27	42	3.26
22	R frontal lobe, medial gyrus	6	2	− 22	63	3.25
27	L frontal lobe, medial gyrus	8	− 12	31	45	3.22
	L anterior cingulate	32	− 10	22	44	3.22
13	R frontal lobe, medial gyrus	11	2	54	− 11	3.20
11	R lentiform nucleus		32	− 13	2	3.19
17	R frontal lobe, paracentral Lobule	5	8	− 34	54	3.15
	R frontal lobe, paracentral lobule	5	14	− 34	49	2.93
21	L frontal lobe, orbital gyrus	11	− 6	44	− 19	3.10

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