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Table 5 Brain regions with significantly (one tailed Z > 2.75, p < 0.005) greater mental stress-induced activation or deactivation, as measured with [15O]H2O positron emission tomography, in women (n = 9) relative to men (n = 35) with CAD and mental stress-induced myocardial ischemia

From: Sex differences in brain activation patterns with mental stress in patients with coronary artery disease

Voxel number Brain region Brodmann’s area Talairach Z score
X Y Z
Stress activation in women > men
 24 L cerebellum   − 26 − 40 − 18 5.70
 54 R parietal lobe, postcentral gyrus 40 51 − 32 50 5.44
 112 L cerebellum   − 18 − 69 − 18 5.05
  L cerebellum   − 14 − 76 − 13 3.54
 67 R parietal lobe, inferior lobule 40 48 − 58 46 4.97
 35 R cerebellum   46 − 63 − 19 4.53
 33 R cerebellum   10 − 72 − 10 4.38
 112 R posterior cingulate 31 8 − 43 41 4.35
  R parietal lobe, precuneus 7 4 − 51 38 4.18
 12 L occipital lobe, fusiform gyrus 19 − 42 − 65 − 9 4.13
 110 L cerebellum   − 46 − 38 − 32 4.07
  L cerebellum   − 44 − 48 − 25 3.33
  L cerebellum   − 53 − 44 − 35 3.14
 47 L cerebellum   − 42 − 61 − 17 4.02
 36 R frontal lobe, inferior gyrus 44 59 12 13 3.91
 14 R temporal lobe, middle gyrus 39 40 − 65 15 3.81
 15 R parietal lobe, postcentral gyrus 3 59 − 13 44 3.77
 20 R frontal lobe, superior gyrus 9 42 37 32 3.66
 15 L frontal lobe, superior gyrus 10 − 22 63 12 3.54
 19 R cerebellum   24 − 50 − 24 3.54
 41 R parietal lobe, inferior lobule 40 38 − 52 53 3.48
 15 L frontal lobe, middle gyrus 11 − 24 32 − 12 3.37
 13 R frontal lobe, superior gyrus 8 14 48 36 3.33
 12 L parietal lobe, inferior lobule 40 − 61 − 33 33 3.26
 14 R cerebellum   22 − 75 − 15 3.18
 14 R frontal lobe, superior gyrus 10 42 48 23 2.89
Stress deactivation in women > men
 129 R frontal lobe, inferior gyrus 47 24 22 − 20 5.66
  R frontal lobe, orbital gyrus 47 22 30 − 23 4.01
 51 R frontal lobe, superior gyrus 6 14 22 51 5.47
 37 L frontal lobe, medial gyrus 6 − 14 29 36 4.95
 88 R frontal lobe, inferior gyrus 47 44 27 − 6 4.94
  R frontal lobe, inferior gyrus 47 50 34 − 15 3.80
 33 L parietal lobe, supramarginal gyrus 40 − 63 − 43 27 4.91
 52 L frontal lobe, superior gyrus 6 − 4 12 55 4.56
 24 L anterior cingulate 24 − 4 23 24 4.54
 17 L parietal lobe, superior lobule 7 − 26 − 64 50 4.41
 42 R temporal lobe, middle gyrus 21 69 − 45 − 8 4.25
  R temporal lobe, inferior gyrus 20 67 − 47 − 15 2.82
 69 L parietal lobe postcentral gyrus 40 − 26 − 38 49 4.20
  L parietal lobe, postcentral gyrus 5 − 30 − 44 58 3.75
 30 L frontal lobe, precentral gyrus 44 − 63 12 9 4.17
  L frontal lobe, inferior gyrus 45 − 59 18 6 3.94
 53 R temporal lobe, inferior gyrus 21 61 − 9 − 16 4.16
 54 R frontal lobe, subcallosal gyrus 34 16 7 − 14 4.15
 24 R frontal lobe, medial gyrus 9 22 38 23 4.04
 14 L frontal lobe, superior gyrus 8 0 28 49 3.98
 53 L frontal lobe, inferior gyrus   − 53 18 1 3.97
  L frontal lobe, inferior gyrus 47 − 46 14 − 1 3.15
 46 R frontal lobe, medial gyrus 10 10 53 16 3.97
 26 R frontal lobe, middle gyrus 8 28 16 43 3.93
  R frontal lobe, middle gyrus 8 24 22 46 3.24
 15 L frontal lobe, superior gyrus 8 − 22 16 48 3.83
 86 R frontal lobe, middle gyrus 10 44 50 − 7 3.80
  R frontal lobe, middle gyrus 11 40 46 − 17 3.63
 32 L thalamus   − 16 − 27 3 3.78
 32 R parietal lobe, supramarginal gyrus 40 59 − 47 29 3.73
  R parietal lobe, inferior lobule 40 51 − 52 38 3.60
 11 R limbic lobe, cingulate gyrus 32 2 27 34 3.72
 30 R temporal lobe, superior gyrus 22 51 12 − 2 3.70
  R temporal lobe, superior gyrus 38 46 13 − 9 3.62
 35 L frontal lobe, paracentral lobule 5 − 12 − 42 59 3.69
 31 L frontal lobe, medial gyrus 10 − 6 55 7 3.64
 20 R lentiform nucleus   16 − 7 5 3.61
 34 L frontal lobe, paracentral lobule 5 − 6 − 38 52 3.61
  L parietal lobe, precuneus 7 − 12 − 42 47 3.53
 51 R posterior cingulate 29 4 − 36 13 3.53
 12 L frontal lobe, middle gyrus 6 − 38 12 46 3.41
 18 R anterior cingulate 25 4 9 − 7 3.39
 14 L frontal lobe, inferior gyrus 10 − 42 45 3 3.39
 20 L frontal lobe, precentral gyrus 4 − 44 − 18 36 3.39
 12 L frontal lobe, precentral gyrus 4 − 36 − 24 55 3.38
 22 L parietal lobe, postcentral gyrus 3 − 30 − 27 42 3.26
 22 R frontal lobe, medial gyrus 6 2 − 22 63 3.25
 27 L frontal lobe, medial gyrus 8 − 12 31 45 3.22
  L anterior cingulate 32 − 10 22 44 3.22
 13 R frontal lobe, medial gyrus 11 2 54 − 11 3.20
 11 R lentiform nucleus   32 − 13 2 3.19
 17 R frontal lobe, paracentral Lobule 5 8 − 34 54 3.15
  R frontal lobe, paracentral lobule 5 14 − 34 49 2.93
 21 L frontal lobe, orbital gyrus 11 − 6 44 − 19 3.10
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Biology of Sex Differences

ISSN: 2042-6410

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