Fig. 1

Study diagram for days 1 and 2 of the protocol. On day 1, subjects get an injection of [Tc99m] sestamibi followed by SPECT imaging of the heart at rest. Three hours later they undergo speech mental stress followed by injection of [Tc99m] sestamibi and SPECT imaging of the heart with mental stress. On the second day, subjects undergo HR-PET imaging of the brain with stress and control conditions. Subjects undergo eight HR-PET scans after injection of 20 mCi O-15 water, 2 with counting control, 2 with speech control, 2 with arithmetic mental stress, and 2 with speech mental stress