Sex differences in the metabolic effects of the renin-angiotensin system

Table 2 Sex differences in metabolic effects of the RAS in clinical opulations

RAS component	Obesity	Dyslipidemia	Insulin sensitivity	Glucose tolerance	References
Angiotensinogen
Males	UNK	UNK	↓	UNK	[100]
Females	↑	↑	↓	UNK	[100,101,102]
Renin
Males	↑	UNK	↓	↓	[103]
Females	↓, ↑	UNK	↓	↓	[103]
Prorenin
Males	UNK	UNK	UNK	UNK
Females	UNK	UNK	UNK	UNK
Angiotensin II
Males	↑	↑	↓	↓	[104,105,106]
Females	↑	↑	↓	↓	[104, 107]
ACE
Males	-	↑	↓	↓	[108,109,110]
Females	-	↑	↓	↓	[101, 108, 110]
AT₁ receptors
Males	-	↑	↓	↓	[103, 105, 110,111,112,113]
Females	-	↑	↓	↓	[103, 105, 110, 112, 113]
AT₂ receptors
Males	UNK	UNK	UNK	UNK
Females	↓	UNK	↑	↑	[114, 115]
Angiotensin-(1-7)
Males	UNK	UNK	UNK	UNK
Females	UNK	UNK	UNK	UNK
ACE2
Males	UNK	UNK	UNK	UNK
Females	UNK	UNK	UNK	UNK
Mas receptors
Males	↑	UNK	UNK	UNK	[116]
Females	↑	UNK	UNK	UNK	[116]
Alamandine
Males	UNK	UNK	UNK	UNK
Females	UNK	UNK	UNK	UNK

ACE angiotensin-converting enzyme, ACE2 angiotensin-converting enzyme 2, AT₁ angiotensin II type 1, AT₂ angiotensin II type 2, RAS renin-angiotensin system, ↑ increases, ↓ decreases, - neutral effects, UNK information currently unknown

ISSN: 2042-6410