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Fig. 1 | Biology of Sex Differences

Fig. 1

From: Sex differences in the metabolic effects of the renin-angiotensin system

Fig. 1

Simplified diagram of the renin-angiotensin system including sites of action for pharmacological agents targeting this hormonal system. A779, mas receptor antagonist [D-Ala7]-angiotensin-(1-7); ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker; AT1R, angiotensin II type 1 receptor; AT2R, angiotensin II type 2 receptor; AVE0991, orally active mas receptor agonist; C21, compound 21 (AT2R agonist); DIZE, ACE2 activator diminazene aceturate; EMA401, AT2R agonist; HRP, decoy peptide for handle region of the prorenin prosegment; MasR, angiotensin-(1-7) mas receptor; MLDAD, mononuclear leukocyte-derived aspartate decarboxylase; MrgD, mas-related G protein-coupled receptor; NEP, neprilysin; POP, prolyl oligopeptidase; PRR, prorenin receptor; TOP, thimet oligopeptidase; XNT, ACE2 activator xanthenone

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