• PHB and OGT interact with each other and are regulated by sex steroids. In addition, PHB functions a co-repressor of sex steroid receptors • PHB and OGT share similar tyrosine motifs, undergo tyrosine phosphorylation in response to insulin, and negatively regulate insulin signaling • Both interact with a number of insulin signaling intermediates • Both localize to mitochondria and have an important role in mitochondrial functions • Both function as transcriptional regulators • In addition, OGT is an X-linked gene, subject to gene dose compensation, and invariably escape from X chromosome inactivation in different cell types |