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Table 1 Mesor, amplitude and acrophase of MAP, heart rate and locomotor activity at 12 months of age over a 24-h cycle time (CT) following cosinor analyses

From: Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats

  Female Male Two-way ANOVA
Control EtOH-exposed Control EtOH-exposed P trt P sex P trt*sex
SBP
 Mesor (mmHg) 123 ± 1 114 ± 3* 121 ± 3 121 ± 2 P = 0.07 NS NS
 Amplitude (mmHg) 2.6 ± 0.6 2.3 ± 0.4 2.8 ± 0.3 3.4 ± 0.4 NS NS NS
 Acrophase, CT (h) 3.6 ± 1.0 5.8 ± 2.1 5.0 ± 1.4 2.9 ± 0.5 NS NS NS
DBP
 Mesor (mmHg) 87 ± 1 84 ± 2 85 ± 2 83 ± 2 NS NS NS
 Amplitude (mmHg) 2.0 ± 0.5 1.8 ± 0.2 2.1 ± 0.3 2.4 ± 0.4 NS NS NS
 Acrophase, CT (h) 2.8 ± 1.2 4.4 ± 2.4 4.2 ± 1.6 2.1 ± 0.4 NS NS NS
MAP
 Mesor (mmHg) 104 ± 1 98 ± 2 102 ± 2 100 ± 1 P = 0.05 NS NS
 Amplitude (mmHg) 2.2 ± 0.5 2.0 ± 0.3 2.4 ± 0.3 2.8 ± 0.4 NS NS NS
 Acrophase, CT (h) 3.2 ± 1.0 5.1 ± 2.2 4.7 ± 1.5 2.4 ± 0.5 NS NS NS
HR
 Mesor (bpm) 332 ± 9 328 ± 6 286 ± 3 285 ± 6 NS P < 0.0001 NS
 Amplitude (bpm) 24 ± 4 28 ± 3 21 ± 3 31 ± 3 P = 0.04 NS NS
 Acrophase, CT (h) 2.2 ± 0.7 1.6 ± 0.3 1.7 ± 0.6 1.4 ± 0.5 NS NS NS
Activity
 Mesor (AU) 2.0 ± 0.1 2.3 ± 0.1 1.5 ± 0.1 1.6 ± 0.2 NS P = 0.0007 NS
 Amplitude (AU) 1.0 ± 0.2 1.2 ± 0.1 0.6 ± 0.1 0.9 ± 0.1 P = 0.06 P = 0.01 NS
 Acrophase, CT (h) 3.0 ± 1.0 2.1 ± 0.4 2.7 ± 1.0 1.9 ± 0.5 NS NS NS
  1. *P < 0.05 comparing control and EtOH-exposed female offspring and P = 0.07 comparing control/EtOH-exposed male offspring, from Sidak’s multiple comparisons tests