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Table 1 Mesor, amplitude and acrophase of MAP, heart rate and locomotor activity at 12 months of age over a 24-h cycle time (CT) following cosinor analyses

From: Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats

 

Female

Male

Two-way ANOVA

Control

EtOH-exposed

Control

EtOH-exposed

P trt

P sex

P trt*sex

SBP

 Mesor (mmHg)

123 ± 1

114 ± 3*

121 ± 3

121 ± 2

P = 0.07

NS

NS

 Amplitude (mmHg)

2.6 ± 0.6

2.3 ± 0.4

2.8 ± 0.3

3.4 ± 0.4

NS

NS

NS

 Acrophase, CT (h)

3.6 ± 1.0

5.8 ± 2.1

5.0 ± 1.4

2.9 ± 0.5

NS

NS

NS

DBP

 Mesor (mmHg)

87 ± 1

84 ± 2

85 ± 2

83 ± 2

NS

NS

NS

 Amplitude (mmHg)

2.0 ± 0.5

1.8 ± 0.2

2.1 ± 0.3

2.4 ± 0.4

NS

NS

NS

 Acrophase, CT (h)

2.8 ± 1.2

4.4 ± 2.4

4.2 ± 1.6

2.1 ± 0.4

NS

NS

NS

MAP

 Mesor (mmHg)

104 ± 1

98 ± 2

102 ± 2

100 ± 1

P = 0.05

NS

NS

 Amplitude (mmHg)

2.2 ± 0.5

2.0 ± 0.3

2.4 ± 0.3

2.8 ± 0.4

NS

NS

NS

 Acrophase, CT (h)

3.2 ± 1.0

5.1 ± 2.2

4.7 ± 1.5

2.4 ± 0.5

NS

NS

NS

HR

 Mesor (bpm)

332 ± 9

328 ± 6

286 ± 3

285 ± 6

NS

P < 0.0001

NS

 Amplitude (bpm)

24 ± 4

28 ± 3

21 ± 3

31 ± 3†

P = 0.04

NS

NS

 Acrophase, CT (h)

2.2 ± 0.7

1.6 ± 0.3

1.7 ± 0.6

1.4 ± 0.5

NS

NS

NS

Activity

 Mesor (AU)

2.0 ± 0.1

2.3 ± 0.1

1.5 ± 0.1

1.6 ± 0.2

NS

P = 0.0007

NS

 Amplitude (AU)

1.0 ± 0.2

1.2 ± 0.1

0.6 ± 0.1

0.9 ± 0.1

P = 0.06

P = 0.01

NS

 Acrophase, CT (h)

3.0 ± 1.0

2.1 ± 0.4

2.7 ± 1.0

1.9 ± 0.5

NS

NS

NS

  1. *P < 0.05 comparing control and EtOH-exposed female offspring and †P = 0.07 comparing control/EtOH-exposed male offspring, from Sidak’s multiple comparisons tests