Fig. 1
From: Inflammatory responses to dietary and surgical weight loss in male and female mice
Males specifically have impaired metabolism with high-fat diet exposure that resolves with weight loss. WT male and female C57Bl/6J mice were placed on high-fat diet (HFD) starting at 6 weeks of age. After 12 weeks of diet, a group of these mice was switched to normal chow to mimic dietary weight loss (WL). A control group remained on normal chow the entire time (ND). Weekly weights were recorded in males (a) and females (b). Metabolic studies included c fasting glucose and d fasting insulin at 6 weeks of WL and glucose tolerance (GTT) testing at 7 weeks of WL in e males and f females. At 26 weeks of age, animal g weight and tissue weight including h liver, i gonadal white adipose tissue (GWAT), and j inguinal white adipose tissue (IWAT). Statistics from diet and sex interaction in box*p < 0.05, ****p < 0.001. ###p < 0.005 and ####p < 0.001 for comparisons between sexes of the same diet group. N = 4–8 per group. $ Data previously published [23]