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Table 5 Rates of change in postoperative cognitive test scores in men vs. women stratified by APOE4 status—APOE4+ carriers

From: Sex and genetic differences in postoperative cognitive dysfunction: a longitudinal cohort analysis

  Men APOE4+ non-surgical
(slope)
n = 116
Women APOE4+ non-surgical
(slope)
n = 139
Men APOE4+ surgical
(slope)
n = 20
Women APOE4+ surgical
(slope)
n = 41
Surgical-sex interaction on rate of change—carriers (p value)
Global cognitive function tests MMSE − 0.0664115 − 0.0328237 − 0.09733 − 0.03718 < 0.001
CDR-SB 0.6476 0.4505 1.059 0.581 < 0.001
Memory-based tests Logical Memory Delayed Recall − 0.1557 − 0.2307 − 0.5671 − 0.2724 0.01
CERAD Delayed Word List − 0.05731 − 0.04418 − 0.1063 − 0.0451 0.03
Attention-based tests Digit Symbol − 0.4937 − 1.074 − 1.07 − 1.467 0.65
SDMT − 0.1192 − 0.05094 − 0.1983 − 0.08353 0.91
Executive function tests Trails Making Test B 7.437 3.938 6.532 4.561 0.84
Animal Category Fluency − 0.6281 − 0.4697 −0.8696 − 0.5259 0.31
  1. Italicized p values are significant
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