Table 5 Rates of change in postoperative cognitive test scores in men vs. women stratified by APOE4 status—APOE4+ carriers
From: Sex and genetic differences in postoperative cognitive dysfunction: a longitudinal cohort analysis
Men APOE4+ non-surgical (slope) n = 116 | Women APOE4+ non-surgical (slope) n = 139 | Men APOE4+ surgical (slope) n = 20 | Women APOE4+ surgical (slope) n = 41 | Surgical-sex interaction on rate of change—carriers (p value) | ||
|---|---|---|---|---|---|---|
Global cognitive function tests | MMSE | − 0.0664115 | − 0.0328237 | − 0.09733 | − 0.03718 | < 0.001 |
CDR-SB | 0.6476 | 0.4505 | 1.059 | 0.581 | < 0.001 | |
Memory-based tests | Logical Memory Delayed Recall | − 0.1557 | − 0.2307 | − 0.5671 | − 0.2724 | 0.01 |
CERAD Delayed Word List | − 0.05731 | − 0.04418 | − 0.1063 | − 0.0451 | 0.03 | |
Attention-based tests | Digit Symbol | − 0.4937 | − 1.074 | − 1.07 | − 1.467 | 0.65 |
SDMT | − 0.1192 | − 0.05094 | − 0.1983 | − 0.08353 | 0.91 | |
Executive function tests | Trails Making Test B | 7.437 | 3.938 | 6.532 | 4.561 | 0.84 |
Animal Category Fluency | − 0.6281 | − 0.4697 | −0.8696 | − 0.5259 | 0.31 | |