Table 1 Representative associations of SNPs on X chromosome for combined samples
From: X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma
| Â | Discovery (Guangdong) | Replication 1 (Malaysia) | Replication 2 (Taiwan) | Combined analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marker | Position | Annotation | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | I 2 | OR | 95% CI | P |
rs5927056 | 31969744 | DMD | 0.81 | 0.73–0.89 | 1.49 × 10−5 | 1.01 | 0.83–1.22 | 9.47 × 10−1 | 0.9 | 0.74–1.11 | 3.33 × 10−1 | 0.00 | 0.85 | 0.79–0.92 | 9.44 × 10−5 |
rs6641142 | 4825493 | 299 kb 3′ of LOC101928201 | 1.28 | 1.14–1.43 | 2.86 × 10−5 | 0.95 | 0.76–1.19 | 6.58 × 10−1 | 1.12 | 0.89–1.41 | 3.44 × 10−1 | 0.00 | 1.19 | 1.08–1.30 | 3.01 × 10−4 |
rs12860876 | 17037354 | REPS2 | 1.20 | 1.09–1.31 | 7.20 × 10−5 | 0.95 | 0.81–1.12 | 5.58 × 10−1 | 1.01 | 0.85–1.21 | 8.86 × 10−1 | 68.81 | 1.07 | 0.92–1.23 | 3.98 × 10−1 |
rs2207942 | 145630047 | 261 kb 5′ of CXorf51A | 1.18 | 1.08–1.29 | 4.02 × 10−4 | 1.14 | 0.96–1.36 | 1.43 × 10−1 | 0.96 | 0.79–1.17 | 7.04 × 10−1 | 0.00 | 1.14 | 1.06–1.23 | 7.30 × 10−4 |
rs2018094 | 12272097 | FRMPD4 | 0.86 | 0.78–0.94 | 7.69 × 10−4 | 0.96 | 0.81–1.14 | 6.44 × 10−1 | 0.96 | 0.8–1.16 | 6.86 × 10−1 | 0.00 | 0.89 | 0.83–0.96 | 1.95 × 10−3 |
rs5910990 | 119872266 | 108 kb 3′ of C1GALT1C1 | 0.86 | 0.79–0.93 | 3.86 × 10−4 | 1.06 | 0.90–1.25 | 4.89 × 10−1 | 1.04 | 0.86–1.25 | 6.97 × 10−1 | 69.11 | 0.96 | 0.83–1.12 | 6.17 × 10−1 |
rs6528069 | 21915630 | 43 kb 5′ of SMS | 0.85 | 0.78–0.93 | 2.41 × 10−4 | 1.11 | 0.94–1.31 | 2.07 × 10−1 | 1.11 | 0.92–1.34 | 2.76 × 10−1 | 80.29 | 1.00 | 0.83–1.21 | 9.86 × 10−1 |
rs5949698 | 95161542 | 430 kb 5′ of BRDTP1 | 1.22 | 1.10–1.37 | 3.40 × 10−4 | 0.86 | 0.70–1.05 | 1.39 × 10−1 | 0.91 | 0.73–1.12 | 3.74 × 10−1 | 80.91 | 1.00 | 0.79–1.26 | 9.90 × 10−1 |