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Table 2 Fatty acid profile (FAME measured by GC-FID) in liver, gAT and iAT

From: Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse

  Fatty acids F M   P values
LIVER Total C16 34.5 ± 0.8 32.9 ± 0.3   ns
Total C18 63.6 ± 0.3 64.7 ± 0.6   ns
Total C20 1.2 ± 0.4 1.8 ± 0.3   ns
C18:0/C16:0 0.02 ± 0.01 0.09 ± 0.01 ** P < 0.01
C18:1/C18:0 146 ± 46 25 ± 3 * P < 0.05
C16:0/C18:2 10.2 ± 0.8 4.3 ± 0.6 ** P < 0.01
Total SFA (%) 27.2 ± 0.4 27.5 ± 0.5   ns
Total MUFA (%) 69.3 ± 0.2 65.4 ± 1.2 * P < 0.05
Total PUFA (%) 3.0 ± 0.3 7.2 ± 0.8 ** P < 0.01
MUFA/SFA 2.5 ± 0.0 2.4 ± 0.1   ns
PUFA/SFA 0.1 ± 0.0 0.3 ± 0.0 ** P < 0.01
MUFA/PUFA 22.4 ± 1.9 9.6 ± 1.3 ** P < 0.01
gAT Total C16 53.2 ± 3.6 43.8 ± 0.8 * P < 0.05
Total C18 45.9 ± 3.4 55.2 ± 0.9 * P < 0.05
C16:1/C16:0 0.46 ± 0.03 0.35 ± 0.02 * P < 0.05
Total SFA (%) 37.1 ± 3.2 33.3 ± 0.4   ns
Total MUFA (%) 45.5 ± 1.2 45.2 ± 1.5   ns
Total PUFA (%) 18.8 ± 0.4 21.3 ± 1.6   ns
MUFA/SFA 1.3 ± 0.1 1.4 ± 0.1   ns
PUFA/SFA 0.6 ± 0.0 0.6 ± 0.1   ns
MUFA/PUFA 2.5 ± 0.1 2.2 ± 0.2   ns
iAT Total C16 42.2 ± 4.4 35.3 ± 2.4   ns
Total C18 55.0 ± 3.7 66.0 ± 2.3 * P < 0.05
C16:1/C16:0 0.49 ± 0.03 0.42 ± 0.08   ns
Total SFA (%) 30.2 ± 3.4 26.0 ± 0.7   ns
Total MUFA (%) 50.3 ± 2.2 48.0 ± 2.7   ns
Total PUFA (%) 18.5 ± 0.8 28.5 ± 2.0 * P ≤ 0.01
MUFA/SFA 1.7 ± 0.2 1.8 ± 0.1   ns
PUFA/SFA 0.6 ± 0.1 1.1 ± 0.1 * P < 0.05
MUFA/PUFA 2.7 ± 0.1 1.7 ± 0.2 * P ≤ 0.01
  1. Data are presented as mean ± sem, n = 3–4. Differences between sexes were determined by two-tailed Student’s t test with statistical significance determined using the Holm-Sidak method, with alpha = 5.000%. Each row was analyzed individually, without assuming a consistent SD. *, P < 0.05, **, P < 0.01, M vs F were considered significant. ns = not significant. M male, F female, SFA saturated fatty acid, MUFA monounsaturated fatty acid, PUFA polyunsaturated fatty acid, gAT perigonadal adipose tissue and iAT inguinal adipose tissue