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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Female-biased sexual dimorphism of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis

Fig. 5

Effects of sex or gonadectomy on the morphological features of Venus-expressing neurons in alBNST or ovBNST. Effects of sex or GDX on the number of Venus-expressing neurons in ovBNST (a) or alBNST (b). Groups of Sham-orchiectomized males (intact), orchiectomized males (ORX), Sham-ovariectomized proestrous females (proestrous), and ovariectomized females (OVX) were analyzed by two-way ANOVA. There was a significant interaction between sex and GDX in both subnuclei. Multiple comparisons test indicated female predominance in the number of Venus-expressing neurons in either ovBNST or alBNST. ovBNST: *p < 0.01 vs. intact males, **< 0.0001 vs. intact males,  p < 0.0001 vs. proestrous females, p < 0.01 vs. ORX. alBNST: *p < 0.05 vs. intact males, p < 0.05 vs. proestrous females. Effects of sex or GDX on the total number of neurons in ovBNST (c) or alBNST (d). As regards the total number of neurons, there was a significant main effect of sex in either ovBNST (c) or alBNST (d), but there was no interaction between sex and GDX, nor was these a main effect of GDX. *, p < 0.05. Effects of sex or GDX on the volume of ovBNST (e) or alBNST (f). There was a significant main effect of sex on the volume of the nucleus in either ovBNST (e) or alBNST (f), but there was no an interaction between sex and GDX, nor was these a main effect of GDX. **, p < 0.01, *, p < 0.05. Effects of sex or GDX on the number of glia in ovBNST (g) or alBNST (h). Neither an interaction between sex and GDX nor a significant main effect of sex or GDX was observed for the number of glial cells in either ovBNST (g) or alBNST (h)

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