Fig. 9

Long-term HFD exposure does not accentuate the NOP receptor-mediated activation of GIRK channels in male eGFP-POMC mice. Membrane current traces showing the N/OFQ- induced outward current seen in chow-fed (a; n = 14) and HFD-fed (b; n = 18) animals. The composite bar graph in (c, d) further illustrates the N/OFQ-induced increase in Δg seen in chow-fed and HFD-fed animals. Bars represent the means for each group while the lines are indicative of 1 SEM