Skip to main content
Fig. 13 | Biology of Sex Differences

Fig. 13

From: Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner

Fig. 13

E2 dampens N/OFQ-induced GIRK channel activation in SF-1 neurons from chow- and HFD-fed OVX NR5A1-Cre females. Membrane current traces show the N/OFQ-induced outward current in chow-fed as well as HFD-fed ethanol vehicle-treated slices (a; n = 6 and c; n = 7) and the attenuation of this effect for both diets in E2-treated slices (b; n = 5 and d; n = 8). These effects are paralleled by similar diminutions in the N/OFQ-induced increase in slope conductance and membrane current (at − 60 mV) seen in (e and f), respectively. *p < 0.05, relative to EtOH-treated vehicle, multi-factorial ANOVA/LSD

Back to article page