Skip to main content
Fig. 11 | Biology of Sex Differences

Fig. 11

From: Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner

Fig. 11

HFD accentuates whereas E2 attenuates N/OFQ-induced GIRK channel activation in POMC neurons from OVX eGFP-POMC females. Membrane current traces show the N/OFQ-induced outward current in chow-fed ethanol (EtOH) vehicle-treated slices (a; n = 8), which was further accentuated in HFD-fed ethanol vehicle-treated slices (c; n = 9), and the attenuation of this effect for both diets in E2-treated slices (b; n = 7 and d; n = 8). These effects are paralleled by similar changes in the N/OFQ-induced increase in composite slope conductance and membrane current (at − 60 mV) seen in (e and f), respectively. *p < 0.05, relative to EtOH-treated vehicle, multi-factorial ANOVA/LSD. #p < 0.05, relative to chow-fed controls, multi-factorial ANOVA/LSD

Back to article page