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Table 3 Expression of genes coding for cannabinoid receptors (CB1–CNR1, CB2–CNR2), S100A6 and CacyBP/SIP in male and female hearts

From: Sex differences in distribution of cannabinoid receptors (CB1 and CB2), S100A6 and CacyBP/SIP in human ageing hearts

Group of patients   Expression of genes
No. of patients CB1 CB2 S100A6 CacyBP/SIP
Under 50 years old Overall 11 1.5 ± 0.50 1.2 ± 0.39 0.8 ± 0.21 0.7 ± 0.16
Men 6 1.3 ± 0.50 1.5 ± 0.42 0.9 ± 0.18 0.7 ± 0.21
  Women 5 1.9 ± 0.20 1.0 ± 0.05 0.6 ± 0.11 0.7 ± 0.08
     
Over 50 years old Overall 11 0.8 ± 0.15* 0.8 ± 0.10* 2.2 ± 0.81* 1.4 ± 0.35*
Men 6 0.9 ± 0.14* 0.7 ± 0.08* 2.9 ± 0.47* 1.1 ± 0.21*
  Women 5 0.7 ± 0.09* 0.9 ± 0.08* 1.5 ± 0.24* 1.7 ± 0.17*
    ↓* ↓ ↓* ↑ ↑* ↓ ↑* ↑
  1. Data present mean ± SE
  2. *p < 0.05 patients over 50 vs patients under 50 years old
  3. p < 0.05 women vs men belonging to the same age group