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Fig. 8 | Biology of Sex Differences

Fig. 8

From: Sexually dimorphic metabolic responses mediated by CRF2 receptor during nutritional stress in mice

Fig. 8

Male mice show hepatic steatosis. Representative micrographs showing H&E stained liver sections from WT and Crhr2−/− mice of both sexes. a Normal hepatocyte morphology is evident in chow-fed WT male mice. b Hepatocytes show ballooning with swollen sinusoids (arrows) and fat droplets (arrowheads) suggesting presence of macrovesicular steatosis in HFD-fed WT male mice. c, d Hepatocytes show ballooning and microvesicular steatosis in both chow- and HFD-fed Crhr2 null male mice. e, h The livers of WT and Crhr2 null female mice on either diet show normal hepatocyte morphology and no evidence of steatosis. Scale bars = 50 μm. CV and PV: central and portal veins, respectively; HC: hepatic cords

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