Fig. 3
From: Sexually dimorphic metabolic responses mediated by CRF2 receptor during nutritional stress in mice
Crhr2−/− male mice show elevated blood glucose levels on chow. In GTT, blood glucose was measured by tail vein sampling before glucose administration (baseline; 0 min) and at 30, 60, and 120 min after a bolus of intraperitoneal glucose (2 g/kg) injection. Repeated-measure ANOVA followed by Sidak’s post hoc test was used to analyze GTT data. a In WT male mice, blood glucose levels were significantly elevated at 30 and 60 min time points on HFD vs. chow. b In Crhr2+/− male mice, blood glucose levels did not differ between the diets, but significantly changed over time. c Glucose clearance rate, as reflected by AUC, was significantly elevated in HFD- vs. chow-fed WT male mice, whereas AUC in Crhr2−/− male mice was comparable on HFD and chow. In female (d) WT and (e) Crhr2−/− HFD-fed mice, significant increases in blood glucose levels were noted at 30 and 60 min post glucose injection. f AUC was higher in HFD-fed vs. chow-fed female mice. (n = 8/group/sex)