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Fig. 6 | Biology of Sex Differences

Fig. 6

From: Estrogen rescues heart failure through estrogen receptor Beta activation

Fig. 6

ERβ-agonist therapy is associated with improved systolic function and attenuation of contraction and relaxation defects induced by HF. a RPP was determined right before euthanasia by direct LV catheterization and was calculated as HR × LVDP where LVDP = LVSP − LVEDP. b dP/dtMax (maximum rate of the LV pressure rise, filled bars) and −dP/dtMin (maximum rate of the LV decline) were directly calculated from the recordings. CTRL group consisted of sham-operated mice. *P < 0.05 vs. CTRL, **P < 0.001 vs. CTRL, ***P < 0.0001 vs. CTRL, ^P < 0.05 vs. HF, ^^P < 0.001 vs. HF, and $P < 0.05 vs. PPT (n = 5–7 animals/group)

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