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Fig. 3 | Biology of Sex Differences

Fig. 3

From: Estrogen rescues heart failure through estrogen receptor Beta activation

Fig. 3

ERβ-agonist DPN attenuates both interstitial and perivascular cardiac fibrosis in HF mice. a Representative Masson’s Trichrome staining of LV sections (interstitial, top panels; perivascular, lower panels) in HF mice treated with the ERα-agonist PPT or the ERβ-agonist DPN for 10 days; blue color indicates fibrosis. b Quantification of overall fibrosis expressed as percentage of each high-power field. cg Relative transcript expression of in vivo of profibrotic genes normalized to CTRL (sham-operated mice). GAPDH was used as an internal control (n = 3–6 mice/group). *P < 0.05 vs. CTRL, **P < 0.001 vs. CTRL, ^P < 0.05 vs. HF, ^^P < 0.001 vs. HF, $P < 0.05 vs. DPN, and $$P < 0.001 vs. PPT

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