Fig. 1

Schematic representation of the methodology. Genotype, liver and adipose tissue gene expression data, and hepatic triglyceride phenotypic data from both sexes of the hybrid mouse diversity panel (HMDP) mice were first integrated using Marker Set Enrichment Analysis in the Mergeomics pipeline to predict sex- and tissue-specific pathways perturbed in NAFLD. Then, potential regulatory genes (key drivers) for male-specific, female-specific, and shared pathways were identified using the Key Driver Analysis in Mergeomics. TG triglyceride, eQTL expression quantitative trait loci, GWAS genome-wide association studies