Fig. 2

CT and 1H-MRS for body composition in a 35-year-old woman with obesity (BMI 38 kg/m²). Despite similar age and BMI, the woman had lower visceral adipose tissue and thigh muscle cross sectional area (CSA), lower intrahepatic and intramyocellular lipids and higher thigh subcutaneous adipose tissue compared to the man in Fig. 1, and this was associated with a more favorable cardiometabolic risk profile compared to the man. Fasting LDL cholesterol 104 mg/dL, HDL cholesterol 59 mg/dL, triglycerides 50 mg/dL, glucose 72 mg/dL, insulin 3 μU/mL, HOMA-IR 0.48, 2-h glucose from oral glucose tolerance test 84 mg/dL. a CT of the abdomen at the level of L4 for quantification of visceral adipose tissue (30 cm²) and subcutaneous adipose tissue (450 cm²). b CT of the mid-thigh for quantification of subcutaneous adipose tissue (208 cm²) and muscle (110 cm²). c 1H-MR spectrum of the right hepatic lobe for intrahepatic lipid quantification showing lipid (1.3 ppm) and unsuppressed water (4.7 ppm) resonances. Lipid to water ratio was 0.01. For purposes of visual comparison, the amplitude of unsuppressed water in Figs. 1c and 2c were scaled identically. d 1H-MR spectrum of soleus muscle for intramyocellular lipid quantification showing intramyocellular lipid methylene protons (-CH2) at 1.3 ppm (IMCL), extramyocellular lipid methylene protons (-CH2) at 1.5 ppm (EMCL), residual water peak at 4.7 ppm, and creatine (-CH2) resonance at 3.0 ppm. IMCL/unsuppressed water ratio was 0.02. For purposes of visual comparison, the amplitude of total creatine peaks in Figs. 1d and 2d were scaled identically