Fig. 1

CT and 1H-MRS for body composition in a 35-year-old man with obesity (BMI 37 kg/m²). Fasting LDL cholesterol 118 mg/dL, HDL cholesterol 39 mg/dL, triglycerides 74 mg/dL, glucose 84 mg/dL, insulin 19 μU/mL, HOMA-IR 3.3, 2-h glucose from oral glucose tolerance test 144 mg/dL. a CT of the abdomen at the level of L4 for quantification of visceral adipose tissue (194 cm²) (white diamond) and subcutaneous adipose tissue (open diamond) (458 cm²). b CT of the mid-thigh for quantification of subcutaneous adipose tissue (open diamond) (123 cm²) and muscle (black diamond) (207 cm²). c 1H-MR spectrum of the right hepatic lobe for intrahepatic lipid quantification showing lipid (1.3 ppm) and unsuppressed water (4.7 ppm) resonances. Lipid to water ratio was 0.8. d 1H-MR spectrum of soleus muscle for intramyocellular lipid quantification showing intramyocellular lipid methylene protons (-CH2) at 1.3 ppm (IMCL), extramyocellular lipid methylene protons (-CH2) at 1.5 ppm (EMCL), residual water peak at 4.7 ppm, and creatine (-CH2) resonance at 3.0 ppm. IMCL/unsuppressed water ratio was 0.06