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Table 6 Selection of immunological functions that are related to the genes with a different expression in males and females in both BALB/c and B6 mice in the proximal colon. The z score gives an indication of the activation or inhibition of the functions in males versus females. The number of molecules includes the number of molecules involved in the indicated function (fold-change of 1.2 (up/down) and a p value < 0.05)

From: Sex and strain dependent differences in mucosal immunology and microbiota composition in mice

Diseases or functions annotation z score BALB/c z score B6 p value BALB/c p value B6 # Mol. BALB/ca # Mol. B6a
Quantity of leukocytes 2.743 − 5.066 2.57E-11 4.64E-21 113 292
Quantity of lymphocytes 2.803 − 5.853 2.71E-09 2.45E-14 87 215
Quantity of T lymphocytes 2.638 −4.628 4.40E-07 1.46E-09 64 154
Quantity of granulocytes − 0.018 0.063 5.13E-07 4.60E-12 42 104
Quantity of antigen presenting cells 2.556 − 1.933 6.91E-06 3.42E-08 35 82
Quantity of macrophages 1.925   1.03E-04   25  
Quantity of B lymphocytes 1.750 − 3.840 3.85E-05 3.11E-09 40 104
Quantity of dendritic cells 2.980   1.62E-04   17  
Proliferation of immune cells 0.895 − 2.700 5.17E-11 3.03E-12 100 228
Proliferation of lymphocytes 1.046 − 1.941 5.22E-10 3.57E-11 91 208
Proliferation of T lymphocytes 0.311   9.85E-10   78  
Homing of leukocytes 4.371 − 4.686 1.81E-08 2.24E-12 52 122
Homing of lymphocytes 4.226   2.67E-08   28  
Homing of T lymphocytes 3.798   4.00E-10   26  
Homing of helper T lymphocytes 2.805   1.41E-06   9  
Homing of regulatory T lymphocytes 1.980   1.69E-04   4  
Activation of leukocytes 2.053 − 3.085 1.15E-05 4.66E-18 74 225
Activation of T lymphocytes 1.303 − 1.944 1.01E-04 1.88E-08 40 105
Differentiation of neutrophils 0.599   2.62E-04   8  
Differentiation of leukocytes 2.423 − 3.410 6.65E-04 2.40E-10 64 190
Differentiation of T lymphocytes 0.697   6.75E-04   39  
T cell development 1.636   3.74E-04   51  
Inflammatory response 3.496 − 3.851 7.30E-10 1.19E-22 95 259
Bacterial Infections 0.179   2.86E-05   46  
  1. aNumber of molecules included in the indicated functions