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Fig. 6 | Biology of Sex Differences

Fig. 6

From: Production of amphiregulin and recovery from influenza is greater in males than females

Fig. 6

Deletion of amphiregulin (Areg) causes greater pulmonary inflammation and reduced pulmonary function in males during H1N1 influenza virus infection. Adult male and female wild-type (Areg+/+) and Areg−/− mice were inoculated intranasally with a low dose of 2009 H1N1 virus and euthanized at 14 days post-inoculation (dpi; n = 5–7/sex/time-point). H&E stained lung sections (a) were scored for inflammation (b n = 6–9/sex/genotype). Pulmonary function tests were performed at 14 dpi and minute ventilation (mL/min; c), elastance (Rrs; d), and lung diffusing capacity (DFCO; e) were measured. The dotted lines represent the value (means ± SEM) for mock-infected mice and bars and represent means ± SEM from two independent experiments, with significant differences represented by asterisks (*)

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