Fig. 6
From: Production of amphiregulin and recovery from influenza is greater in males than females
Deletion of amphiregulin (Areg) causes greater pulmonary inflammation and reduced pulmonary function in males during H1N1 influenza virus infection. Adult male and female wild-type (Areg+/+) and Areg−/− mice were inoculated intranasally with a low dose of 2009 H1N1 virus and euthanized at 14 days post-inoculation (dpi; n = 5–7/sex/time-point). H&E stained lung sections (a) were scored for inflammation (b n = 6–9/sex/genotype). Pulmonary function tests were performed at 14 dpi and minute ventilation (mL/min; c), elastance (Rrs; d), and lung diffusing capacity (DFCO; e) were measured. The dotted lines represent the value (means ± SEM) for mock-infected mice and bars and represent means ± SEM from two independent experiments, with significant differences represented by asterisks (*)