Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats

Table 2 OvaSHR cardiomyopathy score

Hormone	Treatment	n	0	1	1.5	2	2.5	Average
Vehicle	Saline	6	6					0.0
Vehicle	DOX	7			4	1	2	1.9
E2	Saline	7	7					0.0
E2	DOX	7		3	2	2		1.4
E2 + P4	Saline	7	7					0.0
E2 + P4	DOX	7	1	2	3	1		1.2
E2 + Tam	Saline	7	7					0.0
E2 + Tam	DOX	7			4	2	1	1.8
Tam	Saline	7	7					0.0
Tam	DOX	7			3	1	3	2.0
P4	Saline	7	7					0.0
P4	DOX	7	1	1	4	1		1.3

Histopathology of cardiac sections from the ovariectomized SHRs at day 12 was assessed for cardiomyocyte lesions (myofibrillar loss and vacuolization) by a board-certified pathologist. The cardiomyopathy or lesion score indicates the percentage of affected cardiomyocytes within the sampled heart section: 0 is no observed change, 1 is < 5%, 1.5 is 5–15%, 2 is 16–25%, 2.5 is 26–35%, and 3 is > 35%

ISSN: 2042-6410