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Table 2 OvaSHR cardiomyopathy score

From: Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats

Hormone Treatment n 0 1 1.5 2 2.5 Average
Vehicle Saline 6 6      0.0
DOX 7    4 1 2 1.9
E2 Saline 7 7      0.0
DOX 7   3 2 2   1.4
E2 + P4 Saline 7 7      0.0
DOX 7 1 2 3 1   1.2
E2 + Tam Saline 7 7      0.0
DOX 7    4 2 1 1.8
Tam Saline 7 7      0.0
DOX 7    3 1 3 2.0
P4 Saline 7 7      0.0
DOX 7 1 1 4 1   1.3
  1. Histopathology of cardiac sections from the ovariectomized SHRs at day 12 was assessed for cardiomyocyte lesions (myofibrillar loss and vacuolization) by a board-certified pathologist. The cardiomyopathy or lesion score indicates the percentage of affected cardiomyocytes within the sampled heart section: 0 is no observed change, 1 is < 5%, 1.5 is 5–15%, 2 is 16–25%, 2.5 is 26–35%, and 3 is > 35%