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Table 1 SHR cardiomyopathy score

From: Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats

Stage

Treatment

N

0

1

1.5

2

2.5

Average

PRO

Saline

5

5

    

0.0

DOX

5

1

1

2

1

 

1.2

DOX + DRZ

5

1

2

2

  

1.0

EST

Saline

5

1

4

   

0.8

DOX

5

1

1

3

  

1.1

DOX + DRZ

5

1

2

1

1

 

1.1

MET

Saline

5

2

3

   

0.6

DOX

5

1

1

1

2

 

1.3

DOX + DRZ

5

1

2

2

  

1.0

DIE

Saline

5

3

2

   

0.4

DOX

5

  

1

2

2

2.1

DOX + DRZ

5

  

4

1

 

1.6

  1. Histopathology of cardiac sections from the SHRs at day 12 was assessed for cardiomyocyte lesions (myofibrillar loss and vacuolization) by a board-certified pathologist. The cardiomyopathy or lesion score indicates the percentage of affected cardiomyocytes within the sampled heart section: 0 is no observed change, 1 is < 5%, 1.5 is 5–15%, 2 is 16–25%, 2.5 is 26–35%, and 3 is > 35%
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Biology of Sex Differences

ISSN: 2042-6410

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