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Table 1 SHR cardiomyopathy score

From: Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats

Stage Treatment N 0 1 1.5 2 2.5 Average
PRO Saline 5 5      0.0
DOX 5 1 1 2 1   1.2
DOX + DRZ 5 1 2 2    1.0
EST Saline 5 1 4     0.8
DOX 5 1 1 3    1.1
DOX + DRZ 5 1 2 1 1   1.1
MET Saline 5 2 3     0.6
DOX 5 1 1 1 2   1.3
DOX + DRZ 5 1 2 2    1.0
DIE Saline 5 3 2     0.4
DOX 5    1 2 2 2.1
DOX + DRZ 5    4 1   1.6
  1. Histopathology of cardiac sections from the SHRs at day 12 was assessed for cardiomyocyte lesions (myofibrillar loss and vacuolization) by a board-certified pathologist. The cardiomyopathy or lesion score indicates the percentage of affected cardiomyocytes within the sampled heart section: 0 is no observed change, 1 is < 5%, 1.5 is 5–15%, 2 is 16–25%, 2.5 is 26–35%, and 3 is > 35%