Fig. 6

Exogenous 17β-estradiol and progesterone suppresses cardiac damage in ovariectomized SHR. a Serum concentrations of cardiac troponin I (cTnI) were measured from animals that contained pellet implants at days 8 and 12 post DOX treatment (two-way ANOVA, n = 4–6 per implant per treatment, *p  <0.05 according to Tukey’s multiple comparison between implants and treatment). Bars represent the mean ± SEM. b, c Scatter graph to evaluate the relationship between the levels of serum cardiac troponin I and serum E2 or P4 of pellet-implanted SHRs in the presence and absence of DOX treatment at day 12 (n = 3–4 per implant per treatment)