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Fig. 2 | Biology of Sex Differences

Fig. 2

From: Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats

Fig. 2

SHRs treated during proestrus are more sensitive to DOX-induced myocardial damage. a Echocardiograms were performed 12 days post treatment in estrous stage-specific SHRs. Cardiac output, % ejection fraction, and % fractional shortening were analyzed to assess myocardial dysfunction. b Serum concentrations of cardiac troponin I (cTnI) were measured from animals that received estrous stage specific treatments at day 13 post treatment. Bars represent the mean ± SEM. Two-way ANOVA results are displayed in Additional file 2: Table S3. n = 3 animals per treatment per stage. *p < 0.05 according to Tukey’s multiple comparison between stages and treatments, while #p < 0.05 between the indicated groups

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