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Table 1 Summary of included papers performing proper sex stratification in the same order as mentioned in the main text

From: Sex differences in cardiovascular epigenetics—a systematic review

Year First author CVD/risk factor Epigenetics Sample size (% male) Technique Tissue Gene (if applicable) Association Ref.
2017 Mendelson BMI DNA methylation 3743 (48%) Illumina Infinium 450K Whole blood LGALS3BP (unannotated CpG) Stronger for ♂ [12]
2011 Cash Factors associated with obesity and CVD DNA methylation 355 (25%) Bisulphite into pyrosequencing Lymphocytes Global More methylation in ♂ [13]
2013 Guay Blood lipid levels DNA methylation 98 (62%) Bisulphite into pyrosequencing Leukocytes CETP Stronger for ♂ [14]
2014 Guay Plasma lipid levels DNA methylation 98 (62%) Bisulphite into pyrosequencing Leukocytes Multiple   [15]
2013 Zhang Metabolic syndrome DNA methylation 517 (41%) EpiTYPER Leukocytes FABP3   [16]
2013 Johansson Aging DNA methylation 421 (not specified) Illumina Infinium 450K Leukocytes Epigenome-wide   [17]
2016 Horvath Aging DNA methylation 4535 (35%) Illumina Infinium 450K Blood/saliva/brain Epigenome-wide   [18]
2014 Soriano-Tárrago Ischemic stroke DNA methylation 485 (62%) LUMA Whole blood Global Hypomethylation for ♂ [19]
2017 Lin Ischemic stroke DNA methylation 556 (48%) Bisulphite into pyrosequencing Whole blood MMP2 Only for ♂ [20]
2012 Talens Myocardial infarction DNA methylation 248 (52%) Mass spectrometry Leukocytes INS, GNASAS Only in MI samples of ♀ [21]
2013 Jiang Coronary heart disease DNA methylation 72 (50%) Bisulphite into pyrosequencing Whole blood PLA2G7 Only for ♀ [22]
2016 Guo Coronary artery disease DNA methylation 64 (56%) Methylation-specific PCR Whole blood PTX3 Only for ♂ [23]
2014 Zhang CVD mortality DNA methylation 3588 (44%) MALDI-TOF Whole blood F2RL3 Stronger for ♂ [24]
  1. BMI body mass index, Ref reference