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Table 4 IPA summary of females exposed to ozone in the non-proestrus and proestrus stages

From: Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation

Non-proestrus Proestrus
A. Genes targeted by differentially expressed miRNAs
CAMK2N1
CARS
CYP24A1
DBF4
HMGN2
KMT5A
LRRC17
MDH2
MIS18A
PAFAH1B2
PDE4B
PDE7A
PGM3
PNP
REV1
RPS19BP1
RRAD
SEC62
SEC23A
SNX5
SYT4
THAP12
TMED7
TNFAIP2
TNFRSF10C
TP53
UBE2V2
ZNF420
ABCB9
APOO
ARHGEF38
AVEN
CASP3
CCNJ
CMTR2
CNMD
DSCR8
FGD4
FRMD4B
GPR137B
HMBS
METAP1
MITF
MYC
RGMB
SLC14A1
SLC25A27
SLC38A1
TMCC1
TRIM71
XKR8
ZCCHC11
ZIM3
ZNF181
B. Differences in top diseases and biofunctions
Diseases and disorders P value Diseases and disorders P value
 Inflammatory disease 3.84E−02 to 3.84E−05  Organismal injury and abnormalities 4.96E02 to 2.77E14
 Inflammatory response 3.84E02 to 3.84E05  Reproductive system disease 2.15E02 to 2.77E14
 Organismal injury and abnormalities 4.17E02 to 4.17E05  Cancer 4.96E02 to 1.27E10
C. Top molecular and cellular functions
Molecular and cellular Functions P value Molecular and cellular functions P value
 Cellular development 2.05E02 to 5.26E07  Cellular movement 3.77E02 to 4.47E07
 Cellular compromise 3.75E04 to 3.75E04  Cellular death and survival 4.91E02 to 5.61E06
 Cell cycle 2.62E03 to 2.62E03  Cellular development 4.97E02 to 1.38E06
D. Top physiological system development and function
Development and function P value Development and function P value
 Organismal development 4.17E02 to 1.31E03  Embryonic development 3.30E02 to 2.12E05
 Embryonic development 1.29E02 to 1.29E02  Connective tissue development and function 1.79E02 to 6.10E05
 Connective tissue development and function 1.93E02 to 1.93E02  Tissue morphology 7.88E05 to 7.88E05
E Top associated network functions
Associated network functions Score Associated network functions Score
 Cellular development, inflammatory disease, inflammatory response 6  Organismal injury and abnormalities, reproductive system disease, cancer 19