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Table 4 IPA summary of females exposed to ozone in the non-proestrus and proestrus stages

From: Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation

Non-proestrus Proestrus
A. Genes targeted by differentially expressed miRNAs
CAMK2N1 CARS CYP24A1 DBF4 HMGN2 KMT5A LRRC17 MDH2 MIS18A PAFAH1B2 PDE4B PDE7A PGM3 PNP REV1 RPS19BP1 RRAD SEC62 SEC23A SNX5 SYT4 THAP12 TMED7 TNFAIP2 TNFRSF10C TP53 UBE2V2 ZNF420 ABCB9 APOO ARHGEF38 AVEN CASP3 CCNJ CMTR2 CNMD DSCR8 FGD4 FRMD4B GPR137B HMBS METAP1 MITF MYC RGMB SLC14A1 SLC25A27 SLC38A1 TMCC1 TRIM71 XKR8 ZCCHC11 ZIM3 ZNF181
B. Differences in top diseases and biofunctions
Diseases and disorders P value Diseases and disorders P value
 Inflammatory disease 3.84E−02 to 3.84E−05  Organismal injury and abnormalities 4.96E02 to 2.77E14
 Inflammatory response 3.84E02 to 3.84E05  Reproductive system disease 2.15E02 to 2.77E14
 Organismal injury and abnormalities 4.17E02 to 4.17E05  Cancer 4.96E02 to 1.27E10
C. Top molecular and cellular functions
Molecular and cellular Functions P value Molecular and cellular functions P value
 Cellular development 2.05E02 to 5.26E07  Cellular movement 3.77E02 to 4.47E07
 Cellular compromise 3.75E04 to 3.75E04  Cellular death and survival 4.91E02 to 5.61E06
 Cell cycle 2.62E03 to 2.62E03  Cellular development 4.97E02 to 1.38E06
D. Top physiological system development and function
Development and function P value Development and function P value
 Organismal development 4.17E02 to 1.31E03  Embryonic development 3.30E02 to 2.12E05
 Embryonic development 1.29E02 to 1.29E02  Connective tissue development and function 1.79E02 to 6.10E05
 Connective tissue development and function 1.93E02 to 1.93E02  Tissue morphology 7.88E05 to 7.88E05
E Top associated network functions
Associated network functions Score Associated network functions Score
 Cellular development, inflammatory disease, inflammatory response 6  Organismal injury and abnormalities, reproductive system disease, cancer 19