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Table 2 Summary obtained from IPA analysis of FA and O3 exposed male and female mice

From: Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation

Males Females
A. Genes targeted by differentially expressed miRNAs
ARHGEF38 Cg CPEB2 CPEB3 ENTPD7 EPHB6 FAM35A GAREM1 GPR63 Gulo IL6 KIAA1328 MIGA1 NT5DC1 PLAT RFX7 SECISBP2L SKIDA1 SLC38A1 TMCC1 TMEM110 MEM55A TSPAN13 UTS2B XKR8 ZCCHC11 APCDD1 ARHGAP12 BTG1 C2orf15 CMTR2 COX8C DYNC1LI2 ENPP5 FBXO48 FICD Gulo IL10RB INSR MBNL1 PAPD4 PLSCR4 PXK RP11_65D242 RRAGD SLC10A3 SMOC1 SNX2 SOCS5 STIM2 STX6 TMEM170B ULK2
B. Differences in top diseases and biofunctions
Diseases and disorders P value Diseases and disorders P value
 Gastrointestinal disease 4.98E−02 to 3.39E−07  Cancer, organismal injury and abnormalities 4.85E−02 to 2.22E−10
 Inflammatory disease 4.06E−02 to 3.39E−07  Reproductive system disease 3.24E−02 to 2.22E−10
 Inflammatory response 4.06E−02 to 3.39E−07  Endocrine system disease 3.84E−02 to 2.22E−06
C. Top molecular and cellular functions
Molecular and cellular functions P value Molecular and cellular functions P value
 Cell cycle 1.26E−02 to 3.46E−05  Cellular development 4.06E−02 to 2.54E−04
 Cell death and survival 4.95E−02 to 8.00E−05  Cellular growth and proliferation 4.06E−02 to 2.54E−04
 Cellular movement 4.11E−02 to 9.68E−05  Cell morphology 1.10E−02 to 5.62E−04
D. Top physiological system development and function
Development and function P value Development and function P value
 Digestive system development and function 1.51E−02 to 3.39E−07  Organismal development 4.85E−02 to 2.22E−10
 Hepatic system development and function 1.51E−02 to 3.39E−07  Endocrine system disorders 3.84E−02 to 2.22E−06
 Organ development 4.98E−02 to 3.39E−07  Reproductive system development and function 3.24E−02 to 2.22E−10
E. Top associated network functions
Associated network functions Score Associated network functions Score
 Digestive system development and function, gastrointestinal disease, hepatic system development and function 17  Cancer, organismal injury and abnormalities, reproductive system disease 14