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Table 2 Summary obtained from IPA analysis of FA and O3 exposed male and female mice

From: Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation

Males Females
A. Genes targeted by differentially expressed miRNAs
ARHGEF38
Cg
CPEB2
CPEB3
ENTPD7
EPHB6
FAM35A
GAREM1
GPR63
Gulo
IL6
KIAA1328
MIGA1
NT5DC1
PLAT
RFX7
SECISBP2L
SKIDA1
SLC38A1
TMCC1
TMEM110
MEM55A
TSPAN13
UTS2B
XKR8
ZCCHC11
APCDD1
ARHGAP12
BTG1
C2orf15
CMTR2
COX8C
DYNC1LI2
ENPP5
FBXO48
FICD
Gulo
IL10RB
INSR
MBNL1
PAPD4
PLSCR4
PXK
RP11_65D242
RRAGD
SLC10A3
SMOC1
SNX2
SOCS5
STIM2
STX6
TMEM170B
ULK2
B. Differences in top diseases and biofunctions
Diseases and disorders P value Diseases and disorders P value
 Gastrointestinal disease 4.98E−02 to 3.39E−07  Cancer, organismal injury and abnormalities 4.85E−02 to 2.22E−10
 Inflammatory disease 4.06E−02 to 3.39E−07  Reproductive system disease 3.24E−02 to 2.22E−10
 Inflammatory response 4.06E−02 to 3.39E−07  Endocrine system disease 3.84E−02 to 2.22E−06
C. Top molecular and cellular functions
Molecular and cellular functions P value Molecular and cellular functions P value
 Cell cycle 1.26E−02 to 3.46E−05  Cellular development 4.06E−02 to 2.54E−04
 Cell death and survival 4.95E−02 to 8.00E−05  Cellular growth and proliferation 4.06E−02 to 2.54E−04
 Cellular movement 4.11E−02 to 9.68E−05  Cell morphology 1.10E−02 to 5.62E−04
D. Top physiological system development and function
Development and function P value Development and function P value
 Digestive system development and function 1.51E−02 to 3.39E−07  Organismal development 4.85E−02 to 2.22E−10
 Hepatic system development and function 1.51E−02 to 3.39E−07  Endocrine system disorders 3.84E−02 to 2.22E−06
 Organ development 4.98E−02 to 3.39E−07  Reproductive system development and function 3.24E−02 to 2.22E−10
E. Top associated network functions
Associated network functions Score Associated network functions Score
 Digestive system development and function, gastrointestinal disease, hepatic system development and function 17  Cancer, organismal injury and abnormalities, reproductive system disease 14