Table 2 Summary obtained from IPA analysis of FA and O3 exposed male and female mice
From: Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation
Males | Females | ||||
|---|---|---|---|---|---|
A. Genes targeted by differentially expressed miRNAs | |||||
ARHGEF38 Cg CPEB2 CPEB3 ENTPD7 EPHB6 FAM35A GAREM1 GPR63 Gulo | IL6 KIAA1328 MIGA1 NT5DC1 PLAT RFX7 SECISBP2L SKIDA1 | SLC38A1 TMCC1 TMEM110 MEM55A TSPAN13 UTS2B XKR8 ZCCHC11 | APCDD1 ARHGAP12 BTG1 C2orf15 CMTR2 COX8C DYNC1LI2 ENPP5 FBXO48 | FICD Gulo IL10RB INSR MBNL1 PAPD4 PLSCR4 PXK RP11_65D242 | RRAGD SLC10A3 SMOC1 SNX2 SOCS5 STIM2 STX6 TMEM170B ULK2 |
B. Differences in top diseases and biofunctions | |||||
Diseases and disorders | P value | Diseases and disorders | P value | ||
 Gastrointestinal disease | 4.98E−02 to 3.39E−07 |  Cancer, organismal injury and abnormalities | 4.85E−02 to 2.22E−10 | ||
 Inflammatory disease | 4.06E−02 to 3.39E−07 |  Reproductive system disease | 3.24E−02 to 2.22E−10 | ||
 Inflammatory response | 4.06E−02 to 3.39E−07 |  Endocrine system disease | 3.84E−02 to 2.22E−06 | ||
C. Top molecular and cellular functions | |||||
Molecular and cellular functions | P value | Molecular and cellular functions | P value | ||
 Cell cycle | 1.26E−02 to 3.46E−05 |  Cellular development | 4.06E−02 to 2.54E−04 | ||
 Cell death and survival | 4.95E−02 to 8.00E−05 |  Cellular growth and proliferation | 4.06E−02 to 2.54E−04 | ||
 Cellular movement | 4.11E−02 to 9.68E−05 |  Cell morphology | 1.10E−02 to 5.62E−04 | ||
D. Top physiological system development and function | |||||
Development and function | P value | Development and function | P value | ||
 Digestive system development and function | 1.51E−02 to 3.39E−07 |  Organismal development | 4.85E−02 to 2.22E−10 | ||
 Hepatic system development and function | 1.51E−02 to 3.39E−07 |  Endocrine system disorders | 3.84E−02 to 2.22E−06 | ||
 Organ development | 4.98E−02 to 3.39E−07 |  Reproductive system development and function | 3.24E−02 to 2.22E−10 | ||
E. Top associated network functions | |||||
Associated network functions | Score | Associated network functions | Score | ||
 Digestive system development and function, gastrointestinal disease, hepatic system development and function | 17 |  Cancer, organismal injury and abnormalities, reproductive system disease | 14 | ||