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Table 1 Target genes and associated regulatory networks for differentially expressed miRNAs in lung tissue of male and female mice exposed to ozone

From: Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation

A. Genes targeted by differentially expressed miRNAs
BCL2
CDKN1A
COX8C
DDHD1
ENPP5
FBXO48
FGD4
FICD
GPR158
GPR137C
IL6
MARCH4
MBNL2
MYT1L
PCNX1
PTHLH
RDH14
RP11_65D242
SLITRK3
Smad2/3
SMAD6/7
TMEM9B
ZNF800
B. Differences in top diseases and biofunctions
Diseases and disorders P value
 Cancer 4.80E−02 to 4.62E−11
 Organismal injury and abnormalities 4.80E−02 to 4.62E−11
 Reproductive system disease 4.01E−02 to 4.62E−11
 Endocrine system disease 2.28E−02 to 3.11E−07
C. Top molecular and cellular functions
Molecular and cellular functions P value
 Cell cycle 1.23E−02 to 1.87E−05
 Cellular development 4.05E−02 to 5.81E−05
 Cellular growth and proliferation 3.76E−02 to 5.81E−05
D. Top physiological system development and function
Development and function P value
 Organismal development 3.76E−02 to 1.11E−05
 Tissue development 3.76E−02 to 7.49E−04
 Reproductive system development and function 1.04E−02 to 2.99E−03
E. Top associated network functions
Associated network functions Score
 Cancer, organismal injury, and abnormalities 27