Table 1 Target genes and associated regulatory networks for differentially expressed miRNAs in lung tissue of male and female mice exposed to ozone

A. Genes targeted by differentially expressed miRNAs

B. Differences in top diseases and biofunctions

Diseases and disorders

P value

 Cancer

4.80E−02 to 4.62E−11

 Organismal injury and abnormalities

4.80E−02 to 4.62E−11

 Reproductive system disease

4.01E−02 to 4.62E−11

 Endocrine system disease

2.28E−02 to 3.11E−07

C. Top molecular and cellular functions

Molecular and cellular functions

P value

 Cell cycle

1.23E−02 to 1.87E−05

 Cellular development

4.05E−02 to 5.81E−05

 Cellular growth and proliferation

3.76E−02 to 5.81E−05

D. Top physiological system development and function

Development and function

P value

 Organismal development

3.76E−02 to 1.11E−05

 Tissue development

3.76E−02 to 7.49E−04

 Reproductive system development and function

1.04E−02 to 2.99E−03

E. Top associated network functions

Associated network functions

Score

 Cancer, organismal injury, and abnormalities

27