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Fig. 4 | Biology of Sex Differences

Fig. 4

From: Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control

Fig. 4

GPR37L1KO/KO mice are protected from AngII-induced cardiac fibrosis. Images of paraformaldehyde-fixed LV tissue from male (a) and female (b), vehicle- and AngII-treated GPR37L1wt/wt and GPR37L1KO/KO mice were cut into 10-μm sections and stained with Masson’s trichrome to highlight fibrosis (blue) and total tissue (red). Representative images of n ≥ 6. Scale bar size as indicated on figure. Cardiac fibrosis was quantified and expressed as a percent area of total cross-sectional LV area for males (c) and females (d). n ≥ 6, two-way ANOVA results displayed in Additional file 1: Table S3, and *p ≤ 0.05 according to Tukey’s multiple comparisons test

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