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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Effects of gut-derived endotoxin on anxiety-like and repetitive behaviors in male and female mice

Fig. 5

Effects of TLR4 antagonist (+)-naloxone treatment on male and female WT mice. Experiment 2: effects of intraperitoneal injection of TLR4 antagonists and oral gavage of LPS on open field test behavioral outcomes in male and female WT mice. Data presented as sex by (+)-naloxone treatment. a Overall, males spent significantly more time in stereotypic circling than females; however, (+)-naloxone significantly increased time in stereotypic circling in female mice. b In addition, (+)-naloxone significantly increased the number of stereotypic counts in female mice. For jumping behavior, (c) females jumped more than males, and d (+)-naloxone significantly increased jump counts in females. Error bars are 95% confidence intervals. *p < 0.05

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