Table 1 Enriched canonical pathways for expressed genes in the late first trimester placenta, by FPKM quartiles
From: Sex differences in the late first trimester human placenta transcriptome
Input | Top canonical pathways | P valuea | # genes |
|---|---|---|---|
Top 25% of genes | EIF2 signaling | 8.25E-55 | 136 |
Regulation of eIF4 and p70S6K signaling | 7.88E-26 | 81 | |
Protein ubiquitination pathway | 5.90E-25 | 111 | |
Mitochondrial dysfunction | 1.07E-22 | 81 | |
Sirtuin signaling pathway | 5.43E-20 | 109 | |
51–75% quartile | Estrogen receptor signaling | 2.12E-10 | 48 |
JAK/STAT signaling | 9.83E-08 | 32 | |
Ceramide signaling | 1.80E-07 | 34 | |
Insulin receptor signaling | 2.18E-07 | 45 | |
STAT3 pathway | 2.57E-07 | 29 | |
26–50% quartile | Melanocyte development and pigmentation signaling | 7.85E-04 | 24 |
NGF signaling | 7.96E-04 | 28 | |
ERK/MAPK signaling | 1.59E-03 | 40 | |
HGF signaling | 1.72E-03 | 26 | |
Acyl-CoA hydrolysis | 1.76E-03 | 6 | |
0–25% quartile | PI3K signaling in B lymphocytes | 9.40E-04 | 21 |
CDP-diacylglycerol biosynthesis I | 1.71E-03 | 7 | |
Wnt/Ca2+ pathway | 2.81E-03 | 12 | |
Phosphatidylglycerol biosynthesis II (non-plastidic) | 2.83E-03 | 7 | |
D-myo-inositol-5-phosphate metabolism | 3.20E-03 | 23 |