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Table 4 Neuroactive steroids in the sciatic nerve of male and female control and diabetics

From: Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features

  Male Female
Ctrl STZ Ctrl STZ
Progesterone 3.17 ± 0.3 3.21 ± 0.5 5.68 ± 0.7 4.00 ± 0.3
Dihydroprogesterone 1.15 ± 0.5 1.92 ± 0.7 17.60 ± 3.6 16.30 ± 3.2
Allopregnanolone 3.28 ± 0.2 7.63 ± 1.7*** 10.50 ± 0.9 10.70 ± 1.4
Isopregnanolone 0.37 ± 0.1 0.27 ± 0.1 16.40 ± 2.2 16.80 ± 4.1
Testosterone 2.59 ± 0.6 0.55 ± 0.4*** 0.42 ± 0.1 0.35 ± 0.1
Dihydrotesterone 12.10 ± 0.8 2.23 ± 0.6*** UDL UDL
5α-Androstane-3α 17β-diol 0.95 ± 0.5 0.31 ± 0.2 0.66 ± 0.3 0.10 ± 0.1
5α-Androstane-3β 17β-diol 5.40 ± 1.3 4.50 ± 0.6 4.21 ± 1.0 5.92 ± 0.6
17α -Estradiol 0.56 ± 0.1 0.63 ± 0.1 0.67 ± 0.1 0.74 ± 0.1
17β -Estradiol 0.43 ± 0.1 0.44 ± 0.1 0.78 ± 0.3 0.60 ± 0.7
  1. Neuroactive steroid levels were evaluated by liquid chromatography tandem mass spectrometry. Data are expressed as pg/mg of tissue ± SEM. The number of animals utilized was 6. Analysis by Student’s t test ***p < 0.001 vs Ctrl
  2. Ctrl control, STZ diabetics, UDL under detection limit
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