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Table 3 Raw behavioral assessment data from females with sham or I/R surgery and uninjured females

From: Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury

  Behavioral assessments
Condition Guarding score (ipsilateral) Guarding score (contralateral)
BL D1 D3 D5 BL D1 D3 D5
Naïve 0.03 ± 0.02 (12) 0.29 ± 0.09 (12)# 0.04 ± 0.02 (6)** 0.01 ± 0.01 (8) 0.0 ± 0.0 (12) 0.08 ± 0.03 (12) 0.04 ± 0.04 (6)** 0.05 ± 0.05 (8)
Sham 0.0 ± 0.0 (12) 0.40 ± 0.09 (12)# 0.23 ± 0.06 (7) 0.05 ± 0.02 (8) 0.01 ± 0.01 (12) 0.11 ± 0.05 (12) 0.21 ± 0.07 (7) 0.02 ± 0.01 (8)
I/R 0.04 ± 0.02 (15) 0.62 ± 0.07 (15)#* 0.32 ± 0.12 (9)# 0.08 ± 0.03 (11) 0.03 ± 0.01 (15) 0.22 ± 0.04 (15)* 0.23 ± 0.08 (9)# 0.05 ± 0.02 (11)
Condition von Frey PWT (g) Grip Strength (g)
BL D1 D3 D5 BL D1 D3 D5
Naïve 2.53 ± 0.37 (12) 1.66 ± 0.22 (12)#** 1.52 ± 0.18 (6)# 1.37 ± 0.13 (8)# 78.8 ± 5.1 (12) 79.8 ± 5.2 (12) 87.64 ± 6.4 (6) 96.7 ± 4.9 (8)#
Sham 1.72 ± 0.24 (12)* 0.97 ± 0.18 (12) 1.17 ± 0.18 (7) 1.46 ± 0.14 (8) 86.6 ± 6.5 (12) 80.8 ± 7.2 (12) 87.5 ± 5.4 (7) 95.7 ± 4.1 (8)
I/R 2.80 ± 0.29 (15) 0.90 ± 0.13 (15)# 0.97 ± 0.18 (9)# 1.44 ± 0.15 (11)# 88.8 ± 5.2 (15) 78.5 ± 5.8 (15)# 92.2 ± 6.1 (9) 93.9 ± 4.3 (11)
  1. Values are presented as mean ± SEM (N), and analysis was performed using two-way RM ANOVA on condition x time. For ipsilateral forepaw guarding, main effects of time (p < 0.001) and injury (p = 0.008), and a group x time interaction (p = 0.038) were found. For von Frey, a main effect of time (p < 0.001) and an interaction was found (p = 0.015). For grip strength, a main effect of time was found (p < 0.001). Holm-Sidak post hoc analyses indicated *p < 0.05 vs other conditions, **p < 0.05 vs I/R, #p < 0.01 vs within condition BL. PWT: paw withdrawal threshold
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